Biomarker Discovery and Validation
Currently, there are no early detection methods for screening those who are a high risk of developing head and neck cancer. The objective of this study is to develop saliva based DNA diagnostic tools to detect early stage head and neck cancers in high risk groups (i.e. people who drink excessively and smoke). In addition, other biomolecules (proteins/RNA/cells) will be developed for acceptance as routine diagnostic and prognostic markers.
- Saliva based diagnostic biomarker panel to detect HNSCC at an early stage in people who are at a high risk of developing these cancers.
- A saliva-based method for the detection of HPV-associated oral cancers.
- Salivary glycoproteins as biomarkers for head and neck squamous cell carcinoma.
- To develop a method to detect circulating tumour cells (CTC’s) in metastatic head and neck squamous cell carcinoma.